A Mount Compass man is one of three who will face court on drugs and money laundering charges as a result of a joint investigation between the Serious and Organised Crime Branch and the Australian Federal Police (AFP).
A series of searches found about $1.325 million worth of cannabis, about $175,000 worth of cocaine, and $45,000 in cash.
Detectives searched a house on Lipson Street, Port Adelaide about midday on Tuesday, July 28 and located just under 160kg of cannabis, 0.5kg of cocaine, and $20,000 in cash.
The 52-year-old Mount Compass man was arrested at the property.
Detectives searching an Urrbrae house found a 43-year-old man "uncovering evidence linking him to the seizure of illicit drugs and money seized at Port Adelaide", police said.
A third property search, at Evanston Park, unveiled another $25,000 in cash plus evidence linking a 37-year-old Evanston Park man to the seizure at Port Adelaide.
The men will face charges of trafficking a large commercial quantity of a controlled drug, trafficking in a commercial quantity and money laundering.
Having been refused bail, the trio faced Elizabeth Magistrates Court on Wednesday, July 29.
In total, the seized cannabis would have equated to about 53,000 street deals and the cocaine would have equated to 500 street deals.
AFP Superintendent Gail McClure said police bodies and other partner agencies worked to stop illicit drugs from "reaching the community and causing harm".
"Criminal networks are constantly looking for ways to flout the laws for their own greed and profits and the COVID-19 border restrictions are no exception," she said.
"Police will allege an inter-state truck driver was planning to use his status as an essential worker to transport drugs around the country.
"Criminals should not think they can exploit this global crisis. These arrests and seizures show that we are one step ahead and will continue disrupting criminal ventures and put people before the courts."